Correlation Of Her-2/Neu And Tp53 Expressions With Clinicopathologic Characteristics In Infiltrative Ductal Breast Carcinomas

نویسندگان

  • Amir Pooyan Tabibi Dept. of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Parvin Mahsoni Dept. of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
چکیده مقاله:

  Objective: To review Her-2/neu and Tp53 status and their correlation with all other prognostic clinicopathologic features of infiltrative ductal breast carcinomas. Materials and Methods: This cross sectional study was performed on 139 patients with infiltrative ductal breast carcinoma who were diagnosed between May 2000 and March 2006 at the surgery and pathology departments of Alzahra Hospital, Isfahan, Iran. Immunostaining (IHC) for Tp53 and Her2/neu were performed on formalin-fixed, paraffin-embedded tissues based on an avidin-biotin-peroxidase complex technique. The relationship of these markers with clinicpathologic parameters including age, axillary lymph nodes status, tumor size and histological grade were evaluated. Results: It was found out that Her2/neu-positive cases were greater among metastatic lymph nodes than in patients without metastasis, however it was not significant (p=0.1). A significant association was also observed between Her2/neu status and tumor grading (p=0.01). On the contrary, no association was found with other clinicpathologic parameters. In this study, Tp53 presentation in high-grade carcinomas was significantly more as compared to low grade ones (p=0.03). A significant association was also observed between Tp53 and tumor size (p =0.01). There was no association with menopausal status and lymph node status. Conclusion: IHC determined that Her-2/neu and Tp53 expressions are not associated with nodal and menopause status. Conversely, a correlation was found between Her-2/neu, Tp53 expressions and high histological grade of tumor. However, to validate these findings, long-term prospective studies on patients’ survival are necessary.  

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

correlation of her-2/neu and tp53 expressions with clinicopathologic characteristics in infiltrative ductal breast carcinomas

objective: to review her-2/neu and tp53 status and their correlation with all other prognostic clinicopathologic features of infiltrative ductal breast carcinomas. materials and methods: this cross sectional study was performed on 139 patients with infiltrative ductal breast carcinoma who were diagnosed between may 2000 and march 2006 at the surgery and pathology departments of alzahra hospital...

متن کامل

Immunohistochemical Expression of Nanog and Its Relation with Clinicopathologic Characteristics in Breast Ductal Carcinoma

Background: Cancer stem cells (CSCs) are a group of tumor cells with self-renewal property and differentiation potential. CSCs play a crucial role in malignant progression of several types of tumors. However, what is still controversial is the clinicopathological relationship between Nanog marker and its prognostic value in the patients with breast cancer. The expression of Nanog in the patient...

متن کامل

Correlation of ER, PR and HER-2/Neu with other Prognostic Factors in Infiltrating Ductal Carcinoma of Breast

Background and Objectives: Breast cancer is the most common malignancy among women in the world. The aim of this study was to assess estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu of infiltrating ductal carcinoma (IDC) with tumor size, histologic grade, lymph node metastasis and age. Methods: This study was carried out on 300 tissue blocks ofpatients with ID...

متن کامل

Β-catenin expression in in situ and infiltrative ductal carcinomas of the breast.

OBJECTIVE Cascades that include β-catenin that has a function in adhesion and interaction with tumor suppressor genes such as APC have important roles in many neoplasms. The aim of the current study was to confirm the effect of the β-catenin pathway in breast tumor carcinogenesis and invasion. MATERIAL AND METHOD Polyclonal rabbit β-catenin antibody was applied to 52 cases of infiltrative duc...

متن کامل

Correlation of ER, PR, HER- 2 and P53 Immunoreactions with Clinico-Pathological Features in Breast Cancer

  Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed. Materials and Methods: This cross-sectional study was carried out on 214 patients with BC, who referred to the Cancer Institute of...

متن کامل

Mucinous Carcinoma of the Breast in Comparison with Invasive Ductal Carcinoma: Clinicopathologic Characteristics and Prognosis

PURPOSE Mucinous carcinoma (MC) of the breast is a rare histologic type of mammary neoplasm. The objective of this study was to evaluate the long-term disease-free survival (DFS) and overall survival (OS) of MC. METHODS We conducted a retrospective analysis of all MC cases reported to a database between 1994 and 2010. Clinicopathological characteristics and survival of 268 MC cases were revie...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 3  شماره 2

صفحات  75- 80

تاریخ انتشار 2008-03-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023